Mitochondrial Disorders

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10 Chronic Diseases linked to mitochondrial dysfunction


Mitochondrial Dysfunction Present Early in Alzheimer's, Before Memory Loss
Wednesday, February 29, 2012
ROCHESTER, Minn. — Mitochondria — subunits inside cells that produce energy — have long been thought to play a role in Alzheimer's disease. Now Mayo Clinic researchers using genetic mouse models have discovered that mitochondria in the brain are dysfunctional early in the disease. The findings appear in the journal PLoS ONE.....
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Alzheimer's & Mitochondrial Dysfunction

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis.
A comprehensive literature search was performed to collate evidence of mitochondrial dysfunction in autism spectrum disorders (ASDs) with two primary objectives. First, features of mitochondrial dysfunction in the general population of children with ASD were identified. Second, characteristics of mitochondrial dysfunction in children with ASD and concomitant mitochondrial disease (MD) were compared with published literature of two general populations.......
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Autism & Mitochondrial Dysfunction
Relevance of mitochondrial genetics and metabolism in cancer development.
Cancer cells are characterized in general by a decrease of mitochondrial respiration and oxidative phosphorylation, together with a strong enhancement of glycolysis, the so-called Warburg effect. The decrease of mitochondrial activity in cancer cells may have multiple reasons, related either to the input of reducing equivalents to the electron transfer chain or to direct alterations of the mitochondrial respiratory complexes......
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Cancer & Mitochondrial Dysfunction
Targeting mitochondrial dysfunction in the treatment of
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit.
We report on an audit of 138 ME/CFS patients who attended a private practice and took the ATP Profile biomedical test. The results revealed that all of these patients had measureable mitochondrial dysfunction........
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Chronic Fatigue Syndrome & Mitochondrial Dysfunction
Mitochondrial dysfunction and oxidative stress in insulin resistance.
Evidence is mounting of the involvement of mitochondrial dysfunction in insulin resistance, diabetes and associated complications. This review aims to provide an overview of the effects of insulin resistance on mitochondrial function in several tissues. We consider the pathogenesis of insulin resistance from a mitochondrial perspective and contemplate potential beneficial effects of strategies aimed at modulating mitochondrial function in insulin resistance, including insulin and insulin-sensitizing drugs, antioxidants, and selectively targeting antioxidants to mitochondria........
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Diabetes & Mitochondrial Dysfunction
Mitochondria as a therapeutic target in heart failure.
Heart failure is a pressing public health problem with no curative treatment currently available. The existing therapies provide symptomatic relief, but are unable to reverse molecular changes that occur in cardiomyocytes. The mechanisms of heart failure are complex and multiple, but mitochondrial dysfunction appears to be a critical factor in the development of this disease. Thus, it is important to focus research efforts on targeting mitochondrial dysfunction in the failing heart to revive the myocardium and its contractile function.......
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Heart Disease & Mitochondrial Dysfunction
Mitochondrial dysfunction and human immunodeficiency virus infection
Human immunodeficiency virus (HIV) infection and the pharmacological treatment thereof have both been shown to affect mitochondrial function in a number of tissues, and each may cause specific organ pathology through specific mitochondrial pathways. HIV has been shown to kill various tissue cells by activation of mitochondrial apoptosis. Nucleoside analogues, used extensively to treat HIV infection, are known to influence a number of steps affecting mitochondrial DNA integrity........
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HIV/AIDS & Mitochondrial Dysfunction
Oxidative Toxicity in Neurodegenerative Diseases:
Role of Mitochondrial Dysfunction and Therapeutic Strategies
Besides fluorine, oxygen is the most electronegative element with the highest reduction potential in biological systems. Metabolic pathways in mammalian cells utilize oxygen as the ultimate oxidizing agent to harvest free energy. They are very efficient, but not without risk of generating various oxygen radicals. These cells have good antioxidative defense mechanisms to neutralize these radicals and prevent oxidative stress. However, increased oxidative stress results in oxidative modifications in lipid, protein, and nucleic acids, leading to mitochondrial dysfunction and cell death.........
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Ischemia/Stroke & Mitochondrial Dysfunction
Chronic Fatigue Syndrome Patients Subsequently Diagnosed with Lyme Disease Borrelia burgdorferi:
Evidence for Mycoplasma species Co-Infections
Objective: We examined the blood of 48 North American Chronic Fatigue Syndrome (CFS) patients subsequently diagnosed with Lyme Disease Borrelia burgdorferi and compared these to 50 North American CFS patients without evidence of Borrelia burgdorferi infections for presence of Mycoplasma spp. co-infections using forensic polymerase chain reaction.

Conclusions: The results indicate that a subset of CFS patients show evidence of infection with Borrelia burgdorferi, and a large fraction of these patients were also infected with Mycoplasma fermentans and to a lesser degree with other Mycoplasma species.
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Lyme Disease & Mitochondrial Dysfunction
Mitochondria as a pharmacological target:
Magnum overview.
Mitochondria, responsible for energy metabolism within the cell, act as signaling organelles. Mitochondrial dysfunction may lead to cell death and oxidative stress and may disturb calcium metabolism. Additionally, mitochondria play a pivotal role in cardioprotective phenomena and a variety of neurodegenerative disorders ranging from Parkinson's to Alzheimer's disease......
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Parkinson's Disease & Mitochondrial Dysfunction

List of other Disorders linked to Mitochondrial Dysfunction


Mito~Direct complexes have the ability to scavenge systemic & localized free radicals while delivering ATP Co-Factors to the cell. These Co-Factors are delivered directly to the mitochondria in order to maintain the Electron Transport Chain and ATP energy production. This is the textbook process in which to restore & maintain mitochondrial function and stabilize cellular respiration.


Polygenic and Genetotropic



    Type II diabetes mellitus

    Atherosclerotic heart disease

    Parkinson disease

    Alzheimer dementia

    Congestive heart failure

    Maternally inherited migraine



    Postpartum cardiomyopathy

    Alcoholic myopathy

    Wernicke encephalopathy

    Reye syndrome

    Burkitt lymphoma (BCL2)

    Cancer metastasis (NM23)

    Irritable bowel syndrome

    Gastroparesis-GI dysmotility



    AZT toxicity

    FIAU toxicity

    Lead, cyanide & mercury poisoning

    Ackee fruit toxic hypoglycemia

    Doxorubicin cardiotoxicity

    Aminoglycoside ototoxicity

    Aminoglycoside nephrotoxicity

    Amytal poisoning

    Carbon monoxide poisoning

    Amphotericin nephrotoxicity

    MPTP Parkinsonism

    Vitamin deficiencies:

    pellagra, beriberi,  rickets,

    ICU axonal neuropathy

    Pernicious anemia



    Multiple sclerosis

    Systemic lupus erythematosis

    Rheumatoid arthritis


    Primary biliary cirrhosis

    Procainamide lupus

    Guillain-Barré syndrome


Mendelian (nDNA) disorders: secondary disturbances in mitochondrial function



    Wilson disease

    Batten disease


    Huntington disease

    Menkes disease

    Lesch-Nyhan syndrome