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Mitochondrial Disorders
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| Click on the link in each of the 10 sections below to be directed to more articles and published studies. |
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10 Chronic Diseases
linked to mitochondrial dysfunction
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ALZHEIMER'S REPORTS
Mitochondrial Dysfunction Present Early in Alzheimer's, Before Memory Loss
Wednesday, February 29, 2012
ROCHESTER, Minn. — Mitochondria — subunits inside cells
that produce energy — have long been thought to play a
role in Alzheimer's disease. Now Mayo Clinic researchers
using genetic mouse models have discovered that
mitochondria in the brain are dysfunctional early in the
disease. The findings appear in the journal PLoS
ONE.....
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articles and clinical studies Alzheimer's & Mitochondrial Dysfunction |
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AUTISM REPORTS
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis.
Abstract
A comprehensive literature search was performed to
collate evidence of mitochondrial dysfunction in autism
spectrum disorders (ASDs) with two primary objectives.
First, features of mitochondrial dysfunction in the
general population of children with ASD were identified.
Second, characteristics of mitochondrial dysfunction in
children with ASD and concomitant mitochondrial disease
(MD) were compared with published literature of two
general populations.......
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articles and clinical studies Autism & Mitochondrial Dysfunction |
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CANCER REPORTS
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Relevance of mitochondrial genetics and
metabolism in cancer development.
Abstract
Cancer cells are characterized in general by a
decrease of mitochondrial respiration and oxidative
phosphorylation, together with a strong enhancement
of glycolysis, the so-called Warburg effect. The
decrease of mitochondrial activity in cancer cells
may have multiple reasons, related either to the
input of reducing equivalents to the electron
transfer chain or to direct alterations of the
mitochondrial respiratory complexes......
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articles and clinical studies Cancer & Mitochondrial Dysfunction |
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CHRONIC FATIGUE SYNDROME
REPORTS
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Targeting mitochondrial dysfunction in
the treatment of
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit.
Abstract
We report on an audit of 138 ME/CFS patients who
attended a private practice and took the ATP
Profile biomedical test. The results revealed
that all of these patients had measureable
mitochondrial dysfunction........
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articles and clinical studies Chronic Fatigue Syndrome & Mitochondrial Dysfunction |
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DIABETES REPORTS
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Mitochondrial dysfunction and
oxidative stress in insulin resistance.
Abstract
Evidence is mounting of the involvement of
mitochondrial dysfunction in insulin
resistance, diabetes and associated
complications. This review aims to provide
an overview of the effects of insulin
resistance on mitochondrial function in
several tissues. We consider the
pathogenesis of insulin resistance from a
mitochondrial perspective and contemplate
potential beneficial effects of strategies
aimed at modulating mitochondrial function
in insulin resistance, including insulin and
insulin-sensitizing drugs, antioxidants, and
selectively targeting antioxidants to
mitochondria........
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| Read more
articles and clinical studies Diabetes & Mitochondrial Dysfunction |
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HEART DISEASE REPORTS
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Mitochondria as a therapeutic
target in heart failure.
Abstract
Heart failure is a pressing public
health problem with no curative
treatment currently available. The
existing therapies provide symptomatic
relief, but are unable to reverse
molecular changes that occur in
cardiomyocytes. The mechanisms of heart
failure are complex and multiple, but
mitochondrial dysfunction appears to be
a critical factor in the development of
this disease. Thus, it is important to
focus research efforts on targeting
mitochondrial dysfunction in the failing
heart to revive the myocardium and its
contractile function.......
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articles and clinical studies Heart Disease & Mitochondrial Dysfunction |
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HIV/AIDS REPORTS
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Mitochondrial dysfunction
and human immunodeficiency virus
infection
Abstract
Human immunodeficiency virus (HIV)
infection and the pharmacological
treatment thereof have both been
shown to affect mitochondrial
function in a number of tissues, and
each may cause specific organ
pathology through specific
mitochondrial pathways. HIV has been
shown to kill various tissue cells
by activation of mitochondrial
apoptosis. Nucleoside analogues,
used extensively to treat HIV
infection, are known to influence a
number of steps affecting
mitochondrial DNA integrity........
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articles and clinical studies HIV/AIDS & Mitochondrial Dysfunction |
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ISCHEMIA/STROKE REPORTS
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Oxidative Toxicity in Neurodegenerative
Diseases:
Role of Mitochondrial Dysfunction and Therapeutic Strategies
Abstract
Besides fluorine, oxygen is the most electronegative
element with the highest reduction potential in
biological systems. Metabolic pathways in mammalian
cells utilize oxygen as the ultimate oxidizing agent
to harvest free energy. They are very efficient, but
not without risk of generating various oxygen
radicals. These cells have good antioxidative
defense mechanisms to neutralize these radicals and
prevent oxidative stress. However, increased
oxidative stress results in oxidative modifications
in lipid, protein, and nucleic acids, leading to
mitochondrial dysfunction and cell death.........
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articles and clinical studies Ischemia/Stroke & Mitochondrial Dysfunction |
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LYME DISEASE REPORTS
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Chronic Fatigue Syndrome
Patients Subsequently Diagnosed
with Lyme Disease Borrelia
burgdorferi:
Evidence for Mycoplasma
species Co-Infections
Objective: We
examined the blood of 48 North
American Chronic Fatigue
Syndrome (CFS) patients
subsequently diagnosed with Lyme
Disease Borrelia burgdorferi and
compared these to 50 North
American CFS patients without
evidence of Borrelia burgdorferi
infections for presence of
Mycoplasma spp. co-infections
using forensic polymerase chain
reaction.
Conclusions: The results indicate that a subset of CFS patients show evidence of infection with Borrelia burgdorferi, and a large fraction of these patients were also infected with Mycoplasma fermentans and to a lesser degree with other Mycoplasma species. |
| Read more
articles and clinical studies Lyme Disease & Mitochondrial Dysfunction |
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PARKINSON'S DISEASE REPORTS
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Mitochondria as a pharmacological target:
Magnum overview.
Abstract
Mitochondria, responsible for energy metabolism
within the cell, act as signaling organelles.
Mitochondrial dysfunction may lead to cell death and
oxidative stress and may disturb calcium metabolism.
Additionally, mitochondria play a pivotal role in
cardioprotective phenomena and a variety of
neurodegenerative disorders ranging from Parkinson's
to Alzheimer's disease......
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| Read more
articles and clinical studies Parkinson's Disease & Mitochondrial Dysfunction |
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